Stop white-knuckling menopause. Replace the hormones you’re losing.
Estradiol + progesterone, prescribed online by a licensed U.S. clinician. Hormone therapy is the #1 treatment for hot flashes and night sweats.[1]
- Body-wide estradiol + bedtime progesterone
- Strengths set by a licensed U.S. clinician
- 3-minute assessment, no labs to start
- Full 3-month supply ships free, discreetly
Over 50,000 verified, satisfied customers across all Amie products
Not approved? Refunded in full minus the $20 consultation fee.
You’re not imagining it. And you don’t have to tough it out.
- Throwing off damp sheets at midnight
- Wide awake between 2 and 4 AM
- Losing words mid-sentence
- Mood swings, irritability or anxiety
- Low desire, or dryness
- Feeling “not like myself”
It isn’t “just stress.” Estrogen and progesterone fall in perimenopause and menopause. Waiting it out can take years: hot flashes and night sweats lasted a median of 7.4 years in the SWAN study.[2]
Private 3-minute assessment
Two prescription hormones. Two targeted forms. One simple plan.
Hormone therapy cut hot flash frequency by about 75% vs. placebo in a Cochrane review.[3] HRT+ gives you both hormones, each in the form built for it.
Estradiol2× daily
Dissolves between your cheek and gum and is absorbed into your bloodstream, so it works body-wide.[4]
Your strengthClinician-set
Your clinician. They review your symptoms, stage, medications and health history and choose the estradiol and progesterone strengths that fit you.
Takes 3 minutes · no labs to start
Amie HRT+ vs. what you’ve probably tried
| Feature | Amie HRT+ | Estrogen-only HRT | Menopause supplements |
|---|---|---|---|
| Estradiol and progesterone in one plan | ✓ | ✕ | ✕ |
| Oral progesterone at night, the form with the strongest uterine-protection evidence‡ | ✓ | ✕ | ✕ |
| Hormone therapy: #1 treatment for hot flashes† | ✓ | ✓ | ✕ |
| Licensed clinician reviews your history | ✓ | ✓ | ✕ |
| Start online, no labs required | ✓ | Varies | ✓ |
| 30-day money-back guarantee Refunds exclude the $20 clinician consultation fee. | ✓ | — | Varies |
† Per The Menopause Society 2022 hormone therapy position statement. ‡ The Writing Group for the PEPI Trial. JAMA. 1996;275(5):370-375. Comparison is general; your clinician decides which option fits you.
30-day money-back guarantee. Refunds exclude the $20 clinician consultation fee.
Start your private clinician review
- Licensed clinician visit and review
- Prescription for both estradiol and progesterone, strength chosen by your clinician
- Pharmacy compounding and dispensing
- Your personalized dosing schedule
- A full 3-month supply in your first shipment, if prescribed
- Free, discreet shipping
- Care team messaging
$179 due today. Then $99/month starting next month, billed automatically until you cancel. A 3-month supply ships together if prescribed, then every 3 months while prescribed.
Clinician approval comes first. Your purchase stays protected.
Nothing ships unless a licensed U.S. clinician prescribes HRT+. Not approved? Refunded in full minus the $20 consultation fee.
If prescribed, you’re covered by our 30-day money-back guarantee. Refunds exclude the $20 clinician consultation fee.
Three simple steps from here.
- 1
Take the 3-minute assessment
Your symptoms, medications and health history. No labs required to start.
- 2
A licensed clinician reviews it
A licensed U.S. clinician reviews your answers after checkout — usually reviewed within 4 hours. Your strengths are set for you.
- 3
Your 3-month supply ships
If prescribed, a licensed U.S. pharmacy prepares estradiol tablets and progesterone capsules and ships them discreetly.
$179 first month, then $99/month
Your questions, answered.
Is hormone therapy safe for me?
For healthy women under 60, or within 10 years of menopause, The Menopause Society says the benefits of hormone therapy generally outweigh the risks for bothersome symptoms.[1] Hormone therapy isn’t right for everyone. Your clinician reviews your health history, including breast cancer, blood clots, stroke, liver disease and unexplained bleeding, before deciding whether HRT+ is appropriate.
What if the clinician decides I don’t qualify?
Nothing ships. Not approved? Refunded in full minus the $20 consultation fee.
Do I need labs?
No labs are required to get started. If you have recent results you can upload them in the assessment.
What do I pay today?
$179 today covers your first month, including your clinician visit, pharmacy dispensing and your dosing schedule. Then $99/month, billed monthly, until you cancel. A full 3-month supply ships together if prescribed, then every 3 months while prescribed.
What if it’s not for me?
You’re covered by our 30-day money-back guarantee. Refunds exclude the $20 clinician consultation fee. You can also message your care team, or pause or cancel anytime from your account.
How do I take it?
The estradiol tablet dissolves between your cheek and gum, twice a day. The progesterone capsule is taken by mouth once a day. Your clinician gives you exact instructions.
Is HRT+ FDA-approved?
HRT+ Oral is a compounded prescription prepared by a licensed U.S. pharmacy. Compounded medications are not FDA-approved. Your clinician decides whether to prescribe and which strength.
Can I cancel?
Yes. Pause or cancel anytime from your account. Your plan renews monthly until you do.
Stop losing your nights, your focus and yourself to falling hormones.
Take 3 minutes now to find out whether prescription estradiol and progesterone are right for you.
Over 50,000 verified, satisfied customers across all Amie products
Medically reviewed by
Licensed clinicians in Amie’s physician network · Reviewed November 11, 2026
Sources
- The Menopause Society. The 2022 hormone therapy position statement. Menopause. 2022;29(7):767-794.
- Avis NE, et al. Duration of menopausal vasomotor symptoms over the menopause transition (SWAN). JAMA Intern Med. 2015;175(4):531-539.
- MacLennan AH, et al. Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev. 2004;(4):CD002978.
- Price TM, et al. Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17β-estradiol. Obstet Gynecol. 1997;89(3):340-345.
- The Writing Group for the PEPI Trial. Effects of hormone replacement therapy on endometrial histology in postmenopausal women. JAMA. 1996;275(5):370-375.
- Caufriez A, et al. Progesterone prevents sleep disturbances and modulates GH, TSH, and melatonin secretion in postmenopausal women. J Clin Endocrinol Metab. 2011;96(4):E614-E623.
HRT+ Oral is a compounded prescription prepared by a licensed U.S. pharmacy. Compounded medications are not FDA-approved. Your clinician decides whether to prescribe and which strength. Hormone therapy isn’t right for everyone. Your clinician reviews your health history, including breast cancer, blood clots, stroke, liver disease and unexplained bleeding, before deciding whether HRT+ is appropriate. Results vary.
30-day money-back guarantee. Refunds exclude the $20 clinician consultation fee. Not approved? Refunded in full, minus the $20 consultation fee.
$179 due today. Then $99/month starting next month, billed automatically until you cancel. A 3-month supply ships together if prescribed, then every 3 months while prescribed.
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