How Much Does Vyleesi Cost? Price per Dose, Insurance and Savings
The short answer
As listed on vyleesi.com on October 26, 2026, a 4-dose box of Vyleesi costs $99 without insurance coverage, and most commercially insured patients pay $0 through the BlinkRx pharmacy program. At the cash price that is about $25 per use. Vyleesi is an injection used as needed before sex and is FDA-approved only for premenopausal women with acquired, generalized low sexual desire (HSDD).
What does Vyleesi cost?
Vyleesi (bremelanotide) is the brand-name, FDA-approved form of the medicine often called PT-141. It comes as a single-dose autoinjector pen, sold in boxes of four. Here is what vyleesi.com listed when we checked on October 26, 2026:
By the numbers
Vyleesi prices as listed by its maker (Oct 26, 2026)
At the cash price, each dose costs about $25. Because Vyleesi is used only when you plan to have sex, your monthly cost depends on how often you use it: one box a month is $99, and the label’s maximum of 8 doses would be two boxes.
How do you get Vyleesi, and what does the visit cost?
A prescriber sends the prescription to BlinkRx, a digital pharmacy that, according to vyleesi.com, checks your coverage, applies savings offers and ships the pens to your home for free. You can get the prescription from your own doctor or gynecologist, or through a third-party telemedicine partner linked from the Vyleesi site. That site says “fees may apply” for the online visit but did not list an amount when we checked, so confirm the fee before you book.
Does insurance cover Vyleesi?
Coverage varies by plan, and some plans require prior authorization. The maker’s savings program says most eligible patients may pay as little as $0, that eligibility is evaluated individually, that patients must be 18 or older, and that people insured by government-funded programs such as Medicaid or TRICARE are not eligible. The program can be changed or ended at any time, so recheck the terms if you refill over many months.
Who is Vyleesi approved for?
The prescribing information limits Vyleesi to premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD): low desire that developed after a time without problems, happens in every situation, causes marked distress or relationship difficulty, and is not caused by another medical or mental health condition, relationship problems or a medicine. It is not approved after menopause or for men, and it is contraindicated in people with uncontrolled high blood pressure or known cardiovascular disease.
The label also says to stop Vyleesi after 8 weeks if there is no improvement, so a fair trial usually means two or three boxes before you decide.
Is Vyleesi worth the cost?
In the two phase 3 trials, women using Vyleesi had small but statistically significant improvements in desire and less distress about low desire compared with placebo, while the label reports no significant difference in the number of satisfying sexual events. Nausea was common, especially after the first dose; see Vyleesi side effects for the full picture. Whether it is worth the price depends on how it works for you, which is why the 8-week check-in matters.
Vyleesi cost compared with other options
| Option | How it’s used | Listed cash price | FDA status |
|---|---|---|---|
| Vyleesi (bremelanotide) | Injection at least 45 minutes before sex, as needed | $99 per 4-dose box (vyleesi.com) | FDA-approved for HSDD in premenopausal women |
| Addyi (flibanserin) | Pill every night at bedtime | $149 a month via PHILRx (addyi.com) | FDA-approved for HSDD in women under 65 |
| Compounded PT-141 (nasal, troche, tablet) | Varies by pharmacy | Set by each provider | Compounded, not FDA-approved |
More detail: what Addyi costs, PT-141 for women, and PT-141 nasal spray vs troche.
Blys is another option some women consider: a compounded, rapid-dissolve tablet that combines PT-141 with oxytocin and tadalafil, taken 30 to 60 minutes before intimacy, with no injection. It is compounded and not FDA-approved, and because it contains tadalafil it must never be used with nitrate medicines. A licensed clinician reviews your health history and decides whether it is appropriate.
How to keep Vyleesi costs down
- Ask your prescriber to send the prescription to BlinkRx so the maker’s savings program is applied.
- If your plan needs prior authorization, ask whether you will pay the cash price while it is pending.
- Confirm the telehealth visit fee before you book an online consultation.
- Plan your 8-week review so you are not refilling a medicine that isn’t helping.
- Use an HSA or FSA if you have one; confirm eligibility with your plan.
Common questions
How much is Vyleesi without insurance?
Vyleesi's maker lists a 4-dose box at $99 for people without insurance coverage, or whose coverage is denied. That works out to about $25 per dose. Check vyleesi.com or BlinkRx for the current price before you fill.
Is Vyleesi covered by insurance?
Some commercial plans cover it, and the maker says most commercially insured patients pay $0 for a 4-dose box with its savings program. People with government-funded insurance such as Medicaid or TRICARE are not eligible for that program.
Is Vyleesi FDA-approved?
Yes, as an injection for premenopausal women with acquired, generalized hypoactive sexual desire disorder. It is not approved for women after menopause or for men, and compounded nasal sprays, troches or tablets called PT-141 are not FDA-approved.
How many Vyleesi doses can you use a month?
The label says not to use more than one dose in 24 hours, and more than 8 doses a month is not recommended. At the listed cash price, 8 doses would be two boxes, or $198.
Sources
Amie prescribes in all 50 states. Find low libido treatment in your state.