Winona vs Amie HRT+: How Two Online HRT Creams Compare

Winona vs Amie HRT+ at a glance

Both services follow the same basic path: an online health questionnaire, review by a licensed clinician, and a prescription shipped to your door if treatment is appropriate. Both offer a compounded cream that combines estradiol and progesterone. Facts about Winona below come from Winona’s FAQ and products page, read on October 26, 2026. Amie is the publisher of this page, so we have kept the comparison to checkable facts.

How the two creams compare

Each company’s cream is made by a compounding pharmacy, which lets the prescriber choose the strength. Winona owns two 503A compounding pharmacies and also sells separate estrogen and progesterone body creams. Amie HRT+ combines estradiol and progesterone in one cream, with the strength chosen by your clinician.

Because both are compounded, neither cream is FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality before they are used, and a 2020 National Academies report concluded that the evidence for compounded bioidentical hormones is limited. If you prefer an FDA-approved product, Winona sells estrogen tablets, progesterone capsules and an estrogen patch, and any clinician can prescribe FDA-approved estradiol and progesterone.

Visits and access

Winona describes itself as asynchronous: you message your physician through a portal, and it doesn’t offer phone or video calls. That suits people who want no appointments. Amie’s licensed clinician reviews your online intake, usually within 4 hours, and arranges a phone or video visit in states whose telehealth rules require one. You can message the Amie care team with questions.

Coverage is the clearest practical difference. If you live in a state Winona doesn’t list, such as Alabama or Louisiana, you would need another option.

Pricing and refunds

Winona prices each product separately, so a plan with a cream plus a pill or patch costs the sum of each. Its estrogen and progesterone body cream is listed from $89 a month, with “from” prices for the lowest dose. Winona says an order can be cancelled for a full refund only within a 24-hour processing window, and after that it can’t be cancelled, refunded or returned; subscriptions can be paused or cancelled at any time.

Amie HRT+ shows its plan price, including a lower first-month price and a 3-month option, on the card below and at checkout, along with the clinician consultation fee and what happens if you are not approved.

Which might suit you better?

• Winona may suit you if you live in one of its states, want an all-message service, or want to choose between compounded creams and FDA-approved tablets or patches from one company.
• Amie HRT+ may suit you if you want a single combined estrogen and progesterone cream, live in a state Winona doesn’t serve, or prefer a service that arranges a call where your state requires one.
• Your own doctor or an insurance-billed clinic may suit you if you want insurance to cover FDA-approved hormones. See our guide to online HRT providers.