4.8 (from verified patients)

Estriol 0.3% Face Cream

Topical estriol improves skin thickness, collagen, hydration, and reduces fine lines in peri/postmenopausal women.

Rebuilds collagen lost during hormonal decline
Clinically proven to reduce wrinkle depth and skin dryness
Localized application minimizes systemic estrogen exposure
Licensed physician reviews your history and oversees every step of your treatment
80%+ symptom improvement(WHI follow-up studies and clinical guidelines)
Provider
Dr. Sarah M., Board-certified physician · "My patients see real results with this treatment."
3 Month Supply START HERE
$56.66/mo
$169.99 every 3 mo · $1.89/dose

$169.99 billed every 3 months. Cancel anytime.

90-day money back guarantee. No questions.
Order now, ships tomorrow
Not prescribed? You pay nothing Cancel anytime Doctor follow-up included
As Seen On

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary.

As seen in

Well+Good · Women's Health · Forbes · TODAY · mindbodygreen
US-licensed physicians Board-certified in your state
FDA-registered pharmacy US-based, fully licensed
Cancel anytime No contracts, no commitments
HIPAA compliant Your data stays private

Visible improvement, proven ingredients

Dermatologist-trusted actives for real skin transformation

89%
reported clearer skin
within 8-12 weeks
4-6
weeks to see improvement
results build over time
4.8
average patient rating
from verified patients
6,000+
women trust this treatment
prescribed by US providers

*Based on clinical studies of active ingredients. Individual results may vary.

Hear from women like you

Real stories from real patients—no actors, no scripts

Getting started is simple

Real treatment, real doctors, delivered to your door in 3 easy steps

Step 1

Tell us about yourself

Complete a quick 2-minute health assessment. No appointment needed—do it from your couch.

Step 2

Connect with a doctor

A board-certified physician reviews your history and creates a personalized treatment plan.

Step 3

Treatment ships free

Your prescription arrives in discreet packaging within 3-5 days. Ongoing support included.

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Free consultation · No obligation · Cancel anytime

What's inside matters

Pharmaceutical-grade ingredients, compounded for optimal results

Active Ingredient

Personalized dosing

The primary compound that drives results, precisely dosed based on your needs and health profile.

Supporting Compound

Optimal levels

Works synergistically with the primary ingredient to enhance effectiveness and minimize side effects.

Bioavailability Enhancer

Clinically studied

Ensures maximum absorption so you get the full benefit of every dose.

FDA-registered pharmacy GMP certified Third-party tested Made in USA

Your questions, answered

Everything you need to know before getting started

No. Our licensed physicians will evaluate your health history and determine if treatment is right for you. If approved, they'll prescribe and your medication ships directly to your door—no pharmacy visit needed.

Most patients notice initial changes within 2-4 weeks, with full results developing over 8-12 weeks. Your doctor will set realistic expectations based on your specific situation during the consultation.

Yes. Every consultation is reviewed by a US-licensed, board-certified physician—not an algorithm, not a nurse, not a chatbot. Real doctors making real medical decisions about your care.

Absolutely. We're fully HIPAA-compliant with bank-level encryption. Your medication ships in plain, unmarked packaging. No one will know what's inside but you.

If our physicians determine that treatment isn't appropriate for you, you won't be charged anything. We only want you to start treatment if it's genuinely right for your health.

Yes, with no fees or penalties. You can pause, skip a month, or cancel entirely from your account dashboard. We don't believe in trapping customers with fine print.

Everything: the doctor consultation, your prescription medication, free shipping, and unlimited messaging with your care team. No hidden fees, no surprise charges.

The most common side effects are gastrointestinal: nausea, reduced appetite, and occasional constipation. Most patients experience these only during the initial dose titration period (weeks 2-6) and they resolve as your body adjusts. We start at the lowest effective dose precisely to minimize this. If side effects are bothersome, your doctor will slow the titration. Serious side effects are rare but your physician monitors for them throughout your treatment.

Ozempic, Mounjaro, and Wegovy contain the same active ingredients as our compounded versions (semaglutide and tirzepatide). The difference is cost and access. Brand-name GLP-1 medications cost $1,000-$1,300/month without insurance and are frequently out of stock. Our compounded versions use FDA-registered 503B pharmacy facilities, cost a fraction of the brand-name price, and are consistently available. The active ingredient and mechanism of action are identical.

Yes — GLP-1 medications are administered as a subcutaneous (under-the-skin) injection, once weekly. It sounds more intimidating than it is. The pen needle is extremely fine (31 gauge), and the injection goes into a pinch of skin on your abdomen or thigh. Virtually all patients say they were surprised by how easy and painless it became after the first injection. We provide detailed instructions and your doctor is available to guide you through your first dose.

Because the problem isn't your willpower — it's your biology. GLP-1 hormones regulate hunger signals to your brain. In people who struggle to maintain weight loss, this signaling is often dysregulated. No amount of diet or exercise overrides a hormonal imbalance. That's why Amie uses prescription medication prescribed by a licensed physician: it addresses the physiological root cause, not just the symptoms. Clinical trials show patients lose weight they maintain as long as they stay on the medication — which is the point.

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Still have questions? Chat with our team · Cancel anytime

Ready to feel like yourself again?

Get matched with a licensed physician today. No office visits. No commitment. Just results.

US-licensed physicians Free shipping Discreet packaging Cancel anytime 30-day guarantee
Important Safety Information

Who should not use this medication

This medication may not be appropriate for everyone. Do not use if you are pregnant, breastfeeding, or planning to become pregnant. Discuss your complete medical history with your physician before starting treatment.

Possible side effects

Common side effects may include mild nausea, headache, or injection site reactions. Most side effects are temporary and resolve within the first few weeks. Your doctor will discuss what to expect and how to manage any discomfort.

Drug interactions

Tell your doctor about all medications you currently take, including prescriptions, over-the-counter drugs, vitamins, and supplements. Some medications may interact with your treatment.

This is not a complete list of safety information. View full prescribing information.