Estriol 0.3% Face Cream
Topical estriol improves skin thickness, collagen, hydration, and reduces fine lines in peri/postmenopausal women.
$169.99 billed every 3 months. Cancel anytime.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary.
Visible improvement, proven ingredients
Dermatologist-trusted actives for real skin transformation
*Based on clinical studies of active ingredients. Individual results may vary.
Hear from women like you
Real stories from real patients—no actors, no scripts
"I wasn't irritable, I started sleeping again which was a godsend. There are really aren't enough words to explain how much better I feel."
— Martha T.
"No more night sweats, the whole panic attack thing is over. It worked and I could'nt be more happy."
— Linda M.
"I'm 42 and perimenopause, trying out Amie has been incredible, I have no side effects and I feel so much better."
— Amanda C.Getting started is simple
Real treatment, real doctors, delivered to your door in 3 easy steps
Tell us about yourself
Complete a quick 2-minute health assessment. No appointment needed—do it from your couch.
Connect with a doctor
A board-certified physician reviews your history and creates a personalized treatment plan.
Treatment ships free
Your prescription arrives in discreet packaging within 3-5 days. Ongoing support included.
Free consultation · No obligation · Cancel anytime
What's inside matters
Pharmaceutical-grade ingredients, compounded for optimal results
Active Ingredient
Personalized dosingThe primary compound that drives results, precisely dosed based on your needs and health profile.
Supporting Compound
Optimal levelsWorks synergistically with the primary ingredient to enhance effectiveness and minimize side effects.
Bioavailability Enhancer
Clinically studiedEnsures maximum absorption so you get the full benefit of every dose.
Women feeling like themselves again
Real stories from women balancing their hormones

"I was having 10+ hot flashes a day. Within two weeks on bioidentical progesterone, they dropped to maybe one or two. I can sleep again."

"Menopause insomnia was ruining my life. My Amie doctor prescribed progesterone and I am sleeping through the night for the first time in two years."

"I thought being exhausted was just part of getting older. Turns out my hormones were completely off. Three months in and I feel like a different person."

"The anxiety and irritability that came with perimenopause was affecting my relationships. Hormone therapy brought me back to feeling stable and calm."

"My doctor dismissed my symptoms as just stress. My Amie physician actually listened and ran proper labs. I finally have answers and treatment that works."

"DHEA plus progesterone was the combination I needed. The brain fog lifted, my joints stopped aching, and my energy came back. I am 55 and I feel 40."
Your questions, answered
Everything you need to know before getting started
No. Our licensed physicians will evaluate your health history and determine if treatment is right for you. If approved, they'll prescribe and your medication ships directly to your door—no pharmacy visit needed.
Most patients notice initial changes within 2-4 weeks, with full results developing over 8-12 weeks. Your doctor will set realistic expectations based on your specific situation during the consultation.
Yes. Every consultation is reviewed by a US-licensed, board-certified physician—not an algorithm, not a nurse, not a chatbot. Real doctors making real medical decisions about your care.
Absolutely. We're fully HIPAA-compliant with bank-level encryption. Your medication ships in plain, unmarked packaging. No one will know what's inside but you.
If our physicians determine that treatment isn't appropriate for you, you won't be charged anything. We only want you to start treatment if it's genuinely right for your health.
Yes, with no fees or penalties. You can pause, skip a month, or cancel entirely from your account dashboard. We don't believe in trapping customers with fine print.
Everything: the doctor consultation, your prescription medication, free shipping, and unlimited messaging with your care team. No hidden fees, no surprise charges.
The most common side effects are gastrointestinal: nausea, reduced appetite, and occasional constipation. Most patients experience these only during the initial dose titration period (weeks 2-6) and they resolve as your body adjusts. We start at the lowest effective dose precisely to minimize this. If side effects are bothersome, your doctor will slow the titration. Serious side effects are rare but your physician monitors for them throughout your treatment.
Ozempic, Mounjaro, and Wegovy contain the same active ingredients as our compounded versions (semaglutide and tirzepatide). The difference is cost and access. Brand-name GLP-1 medications cost $1,000-$1,300/month without insurance and are frequently out of stock. Our compounded versions use FDA-registered 503B pharmacy facilities, cost a fraction of the brand-name price, and are consistently available. The active ingredient and mechanism of action are identical.
Yes — GLP-1 medications are administered as a subcutaneous (under-the-skin) injection, once weekly. It sounds more intimidating than it is. The pen needle is extremely fine (31 gauge), and the injection goes into a pinch of skin on your abdomen or thigh. Virtually all patients say they were surprised by how easy and painless it became after the first injection. We provide detailed instructions and your doctor is available to guide you through your first dose.
Because the problem isn't your willpower — it's your biology. GLP-1 hormones regulate hunger signals to your brain. In people who struggle to maintain weight loss, this signaling is often dysregulated. No amount of diet or exercise overrides a hormonal imbalance. That's why Amie uses prescription medication prescribed by a licensed physician: it addresses the physiological root cause, not just the symptoms. Clinical trials show patients lose weight they maintain as long as they stay on the medication — which is the point.
Still have questions? Chat with our team · Cancel anytime
Ready to feel like yourself again?
Get matched with a licensed physician today. No office visits. No commitment. Just results.
Important Safety Information
Who should not use this medication
This medication may not be appropriate for everyone. Do not use if you are pregnant, breastfeeding, or planning to become pregnant. Discuss your complete medical history with your physician before starting treatment.
Possible side effects
Common side effects may include mild nausea, headache, or injection site reactions. Most side effects are temporary and resolve within the first few weeks. Your doctor will discuss what to expect and how to manage any discomfort.
Drug interactions
Tell your doctor about all medications you currently take, including prescriptions, over-the-counter drugs, vitamins, and supplements. Some medications may interact with your treatment.
This is not a complete list of safety information. View full prescribing information.