From purchase to door in 3 days Not prescribed? Full refund, automatically Bioidentical HRT · compounded to you Board-certified physicians · 50 states From purchase to door in 3 days Not prescribed? Full refund, automatically Bioidentical HRT · compounded to you Board-certified physicians · 50 states
Home / Treatments / Women's Hormone Therapy
6 protocols · bioidentical · physician-reviewed

Hormones, in balance.

Compounded bioidentical HRT for perimenopause and menopause — estradiol, biestrogen, progesterone, and testosterone. Prescribed by physicians who specialize in menopausal care.

6 Protocols 2–3wk Initial relief 100% Bioidentical
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Every shipment arrives in plain outer packaging with no Amie branding, no medication names, no health identifiers on the outside. The return address is our fulfillment partner, not a medical facility.
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Where to start

Symptom-first matching.

What you're actually experiencing is the best guide to what to try first. A physician confirms the right protocol after reviewing your intake and symptoms.

"Hot flashes, night sweats, and mood swings are wrecking my sleep and my day."
Usually starts with

Start with biestrogen cream

Systemic estrogen addresses vasomotor symptoms (hot flashes, sweats) typically within 2–3 weeks. Biestrogen (80% E2 + 20% E3) adds tissue-level support. Usually paired with progesterone if you have a uterus.

"I sleep poorly, I feel anxious, and something feels 'off' even though I'm barely having hot flashes."
Usually starts with

Try progesterone alone or first

Micronized progesterone often improves sleep and mood within 1–2 cycles. For many women in early perimenopause, progesterone is the first intervention that helps — before estrogen is needed.

"My libido disappeared, my energy is flat, and I've lost muscle tone despite working out."
Usually starts with

Add low-dose testosterone

Women naturally produce testosterone, and low levels contribute to libido loss, low energy, and reduced lean mass. Low-dose testosterone cream is applied daily; most women notice changes within 4–8 weeks.

MD

Menopause specialists

Trained in HRT prescribing

Bioidentical formulations

Body-identical hormones

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Discreet packaging

No branding on the outside

$

Full refund if not approved

Automatic · no forms

Hormone therapy FAQ

Common questions.

The ones we get most in this category. For the full list, see our complete FAQ.

What does "bioidentical" actually mean?

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Bioidentical hormones have the same molecular structure as the hormones your body naturally produces — estradiol (E2), estriol (E3), progesterone, and testosterone. This is different from synthetic hormones (like conjugated equine estrogens or medroxyprogesterone) which have modified structures. Bioidenticals are well-studied and widely prescribed in modern HRT.

Do I need a uterus check or blood work first?

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Most patients don't need labs to start. Your medical intake covers the clinical screening your physician needs. If you have a uterus and are starting estrogen, your physician will prescribe progesterone alongside to protect the uterine lining. Ultrasound is only needed if your history suggests it.

How long until I feel better?

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For hot flashes and night sweats: 2–3 weeks at effective dose. For mood, sleep, and energy: 4–6 weeks. For libido and body composition changes with testosterone: 6–12 weeks. Your physician will adjust dose at the 4-week and 3-month marks based on how you're responding.

Is HRT safe long-term?

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Modern research supports long-term use of bioidentical HRT for most women when started within 10 years of menopause. The risks associated with the old WHI study (conjugated equine estrogens + medroxyprogesterone) don't translate directly to bioidentical hormones at lower doses. Your physician discusses your personal risk profile based on your medical history.

Can I switch between creams, pellets, and oral?

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Yes. Different delivery methods have different absorption profiles, side-effect profiles, and convenience levels. If one isn't working for you, message your physician from your dashboard and they'll work with you to switch.

Ready when you are

Real medicine. Real relief. Delivered discreetly.

Pick your protocol and check out. Complete your medical intake. A menopause-trained physician reviews within 24 hours. If you're not a fit, full refund — automatically.